ea0049oc6.3 | Diabetes therapy and complications | ECE2017
Klovins Janis
, Elbere Ilze
, Peculis Raitis
, Kalnina Ineta
, Zaharenko Linda
, Konrade Ilze
, Pirags Valdis
Metformin is a biguanide class agent widely used as a first-line treatment for type 2 diabetes, however the detailed mode of action and exact pharmacodynamics has not been clarified. Moreover there is no studies in humans displaying the effect of metformin on DNA methylation. We therefore performed a clinical study involving twelve healthy nondiabetic individuals who were subjected to the 1 week of metformin (2×850 mg/day) treatment. Peripheral blood for DNA isolation was...